Narrative Review: Integrated Transitional Care Models for High-Utilizer Patients with Complex Chronic Conditions: A Multidisciplinary Synthesis
Abstract
Background: A small subset of patients with complex chronic conditions, such as heart failure (CHF), chronic obstructive pulmonary disease (COPD), and diabetes with complications, account for a disproportionately high share of emergency department (ED) visits and hospital readmissions. This pattern of high utilization signifies fragmented care, patient distress, and unsustainable system costs, highlighting an urgent need for effective transitional care models. Aim: This narrative review aims to examine the integrated, multidisciplinary care models designed to improve the transition of care for high-utilizer patients, with a focus on preventing recurrent acute care encounters. Methods: A comprehensive search of PubMed, CINAHL, and Web of Science databases was conducted for peer-reviewed literature (2010-2024) addressing interventions involving public health, EMS, nursing, pharmacy, and laboratory/radiology within transitional care frameworks. Results: Evidence robustly supports that coordinated interventions—particularly nurse-led transition coaching, pharmacist-led medication management, and community paramedicine—significantly reduce readmissions and ED visits. Success is contingent on proactive identification of high-risk patients, interprofessional communication, and addressing social determinants of health (SDOH). Interventions that merely provide information without intensive, relationship-based support show limited effectiveness. Conclusion: Breaking the "revolving door" cycle requires moving beyond siloed care to implement proactive, patient-centered models that integrate clinical management with social support. Future efforts must standardize outcome measures, leverage health information technology for real-time data sharing, and advocate for sustainable payment models that reward care coordination and improved patient outcomes
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References
Agarwal, G., Angeles, R., Pirrie, M., Marzanek, F., McLeod, B., Parascandalo, J., & Dolovich, L. (2016). Effectiveness of a community paramedic-led health assessment and education initiative in a seniors’ residence building: the Community Health Assessment Program through Emergency Medical Services (CHAP-EMS). BMC emergency medicine, 17(1), 8. https://doi.org/10.1186/s12873-017-0119-4
Anderson, S. L., & Marrs, J. C. (2018). A review of the role of the pharmacist in heart failure transition of care. Advances in therapy, 35(3), 311-323. https://doi.org/10.1007/s12325-018-0671-7
Berkowitz, S. A., Hulberg, A. C., Hong, C., Stowell, B. J., Tirozzi, K. J., Traore, C. Y., & Atlas, S. J. (2016). Addressing basic resource needs to improve primary care quality: a community collaboration programme. BMJ quality & safety, 25(3), 164-172. https://doi.org/10.1136/bmjqs-2015-004521
Berkowitz, S. A., Parashuram, S., Rowan, K., Andon, L., Bass, E. B., Bellantoni, M., ... & Brown, P. M. (2018). Association of a care coordination model with health care costs and utilization: the Johns Hopkins Community Health Partnership (J-CHiP). JAMA network open, 1(7), e184273-e184273. doi:10.1001/jamanetworkopen.2018.4273
Bodenheimer, T., & Berry-Millett, R. (2009). Follow the money—controlling expenditures by improving care for patients needing costly services. New England Journal of Medicine, 361(16), 1521-1523. DOI: 10.1056/NEJMp0907185
Braet, A., Weltens, C., & Vleugels, A. (2012). Effectiveness of discharge interventions from hospital to home to reduce readmissions: a systematic review. JBI Evidence Synthesis, 10(28), 1-13. DOI: 10.11124/jbisrir-2012-310
Choi, B. Y., Blumberg, C., & Williams, K. (2016). Mobile integrated health care and community paramedicine: an emerging emergency medical services concept. Annals of emergency medicine, 67(3), 361-366. https://doi.org/10.1016/j.annemergmed.2015.06.005
Coleman, E. A., Parry, C., Chalmers, S., & Min, S. J. (2006). The care transitions intervention: results of a randomized controlled trial. Archives of internal medicine, 166(17), 1822-1828. doi:10.1001/archinte.166.17.1822
Conn, V. S., & Ruppar, T. M. (2017). Medication adherence outcomes of 771 intervention trials: systematic review and meta-analysis. Preventive medicine, 99, 269-276. https://doi.org/10.1016/j.ypmed.2017.03.008
Finkelstein, A., Zhou, A., Taubman, S., & Doyle, J. (2020). Health care hotspotting—a randomized, controlled trial. New England Journal of Medicine, 382(2), 152-162. DOI: 10.1056/NEJMsa1906848
Gheorghiade, M., Vaduganathan, M., Fonarow, G. C., & Bonow, R. O. (2013). Rehospitalization for heart failure: problems and perspectives. Journal of the American College of Cardiology, 61(4), 391-403. https://doi.org/10.1016/j.jacc.2012.09.038
Harrison, J. D., Auerbach, A. D., Quinn, K., Kynoch, E., & Mourad, M. (2014). Assessing the impact of nurse post-discharge telephone calls on 30-day hospital readmission rates. Journal of general internal medicine, 29(11), 1519-1525. https://doi.org/10.1007/s11606-014-2954-2
Hasan, O., Meltzer, D. O., Shaykevich, S. A., Bell, C. M., Kaboli, P. J., Auerbach, A. D., ... & Schnipper, J. L. (2010). Hospital readmission in general medicine patients: a prediction model. Journal of general internal medicine, 25(3), 211-219. https://doi.org/10.1007/s11606-009-1196-1
Herron, L. M., Phillips, G., Brolan, C. E., Mitchell, R., O'Reilly, G., Sharma, D., ... & Cox, M. (2022). “When all else fails you have to come to the emergency department”: Overarching lessons about emergency care resilience from frontline clinicians in Pacific Island countries and territories during the COVID-19 pandemic. The Lancet Regional Health–Western Pacific, 25. https://doi.org/10.1016/j.lanwpc.2022.100519
Hesselink, G., Zegers, M., Vernooij-Dassen, M., Barach, P., Kalkman, C., Flink, M., ... & Wollersheim, H. (2014). Improving patient discharge and reducing hospital readmissions by using Intervention Mapping. BMC health services research, 14(1), 389. https://doi.org/10.1186/1472-6963-14-389
Hirschman, K. B., Shaid, E., McCauley, K., Pauly, M. V., & Naylor, M. D. (2015). Continuity of care: the transitional care model. Online J Issues Nurs, 20(3), 1. DOI:10.3912/OJIN.Vol20No03Man01
Hong, C. S., Siegel, A. L., & Ferris, T. G. (2014). Caring for high-need, high-cost patients: what makes for a successful care management program?.
Horwitz, L. I., Wang, Y., Altaf, F. K., Wang, C., Lin, Z., Liu, S., ... & Herrin, J. (2018). Hospital characteristics associated with postdischarge hospital readmission, observation, and emergency department utilization. Medical care, 56(4), 281-289. DOI: 10.1097/MLR.0000000000000882
Hughes, A. M., Baumhover, L. A., Fuchsen, E. A., & Spilman, S. K. (2020). Effect of pain management electronic order sets on opioid use in adult rib fracture patients. Journal of Trauma Nursing| JTN, 27(4), 234-239. DOI: 10.1097/JTN.0000000000000519
Jackson, C., Shahsahebi, M., Wedlake, T., & DuBard, C. A. (2015). Timeliness of outpatient follow-up: an evidence-based approach for planning after hospital discharge. The Annals of Family Medicine, 13(2), 115-122. https://doi.org/10.1370/afm.1753
Jensen, J. L., Marshall, E. G., Carter, A. J., Boudreau, M., Burge, F., & Travers, A. H. (2016). Impact of a novel collaborative long-term care–EMS model: a before-and-after cohort analysis of an extended care paramedic program. Prehospital Emergency Care, 20(1), 111-116. https://doi.org/10.3109/10903127.2015.1051678
Kangovi, S., Mitra, N., Grande, D., White, M. L., McCollum, S., Sellman, J., ... & Long, J. A. (2014). Patient-centered community health worker intervention to improve posthospital outcomes: a randomized clinical trial. JAMA internal medicine, 174(4), 535-543. doi:10.1001/jamainternmed.2013.14327
Kansagara, D., Chiovaro, J. C., Kagen, D., Jencks, S., Rhyne, K., O'Neil, M., ... & Englander, H. (2016). So many options, where do we start? An overview of the care transitions literature. Journal of hospital medicine, 11(3), 221-230. https://doi.org/10.1002/jhm.2502
Lauffenburger, J. C., Ghazinouri, R., Jan, S., Makanji, S., Ferro, C. A., Lewey, J., ... & Choudhry, N. K. (2019). Impact of a novel pharmacist-delivered behavioral intervention for patients with poorly-controlled diabetes: The ENhancing outcomes through Goal Assessment and Generating Engagement in Diabetes Mellitus (ENGAGE-DM) pragmatic randomized trial. PloS one, 14(4), e0214754. https://doi.org/10.1371/journal.pone.0214754
Leppin, A. L., Gionfriddo, M. R., Kessler, M., Brito, J. P., Mair, F. S., Gallacher, K., ... & Montori, V. M. (2014). Preventing 30-day hospital readmissions: a systematic review and meta-analysis of randomized trials. JAMA internal medicine, 174(7), 1095-1107. doi:10.1001/jamainternmed.2014.1608
Moe, J., Kirkland, S. W., Rawe, E., Ospina, M. B., Vandermeer, B., Campbell, S., & Rowe, B. H. (2017). Effectiveness of interventions to decrease emergency department visits by adult frequent users: a systematic review. Academic Emergency Medicine, 24(1), 40-52. https://doi.org/10.1111/acem.13060
Morgan, D. J., Leppin, A. L., Smith, C. D., & Korenstein, D. (2017). A practical framework for understanding and reducing medical overuse: conceptualizing overuse through the patient‐clinician interaction. Journal of hospital medicine, 12(5), 346-351. https://doi.org/10.12788/jhm.2738
Naylor, M. D., Brooten, D. A., Campbell, R. L., Maislin, G., McCauley, K. M., & Schwartz, J. S. (2004). Transitional care of older adults hospitalized with heart failure: a randomized, controlled trial. Journal of the American Geriatrics Society, 52(5), 675-684. https://doi.org/10.1111/j.1532-5415.2004.52202.x
Naylor, M. D., Shaid, E. C., Carpenter, D., Gass, B., Levine, C., Li, J., ... & Williams, M. V. (2017). Components of comprehensive and effective transitional care. Journal of the American Geriatrics Society, 65(6), 1119-1125. https://doi.org/10.1111/jgs.14782
Nguyen-Buckley, C., & Steadman, R. (2018). How to implement evidence-based healthcare. Anesthesia & Analgesia, 126(5), 1777-1778. DOI: 10.1213/ANE.0000000000002842
O’Brien, B. C., Harris, I. B., Beckman, T. J., Reed, D. A., & Cook, D. A. (2014). Standards for reporting qualitative research: a synthesis of recommendations. Academic medicine, 89(9), 1245-1251. DOI: 10.1097/ACM.0000000000000388
Palacio, A., Garay, D., Langer, B., Taylor, J., Wood, B. A., & Tamariz, L. (2016). Motivational interviewing improves medication adherence: a systematic review and meta-analysis. Journal of general internal medicine, 31(8), 929-940. https://doi.org/10.1007/s11606-016-3685-3
Sadowski, L. S., Kee, R. A., VanderWeele, T. J., & Buchanan, D. (2009). Effect of a housing and case management program on emergency department visits and hospitalizations among chronically ill homeless adults: a randomized trial. Jama, 301(17), 1771-1778. doi:10.1001/jama.2009.561
Slazak, E., Cardinal, C., Will, S., Clark, C. M., Daly, C. J., & Jacobs, D. M. (2020). Pharmacist-led transitions-of-care services in primary care settings: opportunities, experiences, and challenges. Journal of the American Pharmacists Association, 60(3), 443-449. https://doi.org/10.1016/j.japh.2019.11.016
Shadmi, E., Key, C., Molcho, T., Low, M., Giveon, S., Lieberman, N., & Balicer, R. D. (2018). Integrated Care for High-need High-cost Patients: The Comprehensive Care for Multimorbid Adults Program (CC-MAP). International Journal of Integrated Care, 18(s2), 24. DOI:10.5334/ijic.s2024
Shah, M. K., Gandrakota, N., Cimiotti, J. P., Ghose, N., Moore, M., & Ali, M. K. (2021). Prevalence of and factors associated with nurse burnout in the US. JAMA network open, 4(2), e2036469-e2036469. doi:10.1001/jamanetworkopen.2020.36469
Whiteside, L. K., Vrablik, M. C., Russo, J., Bulger, E. M., Nehra, D., Moloney, K., & Zatzick, D. F. (2021). Leveraging a health information exchange to examine the accuracy of self-report emergency department utilization data among hospitalized injury survivors. Trauma surgery & acute care open, 6(1). https://doi.org/10.1136/tsaco-2020-000550
Zayas, C. E., He, Z., Yuan, J., Maldonado-Molina, M., Hogan, W. R., Modave, F., ... & Bian, J. (2016, May). Examining Healthcare Utilization Patterns of Elderly and Middle-Aged Adults in the United States. In FLAIRS (pp. 361-367).
Zhang, Y., Grinspan, Z., Khullar, D., Unruh, M. A., Shenkman, E., Cohen, A., & Kaushal, R. (2020, March). Developing an actionable patient taxonomy to understand and characterize high-cost Medicare patients. In Healthcare (Vol. 8, No. 1, p. 100406). Elsevier. https://doi.org/10.1016/j.hjdsi.2019.100406
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Copyright (c) 2024 Abdullah Abdulaziz Ibrahim Alghamdi, Turki Mohammad Ali Khawaji, Rami Redha Abdulrasheed Ambon, Jaber Mufareh Ali Al Huraysi, Dalia Sami Dabash, Mohammed Munis R Alhadhrami, Hesham Yahya Ali Hakami, Amna Obaid Abdo Abu Ayed, Mohammed Hussain Mohammed Alqahtani, Abdullah Mohsen Alotaibi, Abdullah Abdura Hassan Almaleki, Saadi Mousa Alshammari

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