Management of Obstructive Sleep Apnea (OSA) Across the Care Continuum: An Interdisciplinary Narrative Review

Fahd Sari K. Alsharari (1), Sattam Aali Alotaibi (2), Qoot Naif Ayad Alotaibi (3), Nasser Saad Hamed Aldossary (4), Wegdan Husain Ali Mubaraki (5), Yusra Ali Alatawi (6), Yousef Jamman Alharbi (7), Weam Ali Esmael Mobarky (8), Doaa Salim Hamid Alabsi (9), Ali Mousa Mobarki (10), Dr. Othman Mohammed Almousa (11), Hanan Ahmad Alghamdi (12)
(1) Eisawiyah General Hospital,Ministry of Health, Saudi Arabia,
(2) Bajadiyah Hospital, Ministry of Health, Saudi Arabia,
(3) Ruwaidat Al-Ardh Hospital, Ministry of Health, Saudi Arabia,
(4) Wadi Al-Dawasir Hospital, Ministry of Health, Saudi Arabia,
(5) Makramiyah Primary Health Care Center, Ministry of Health, Saudi Arabia,
(6) King Salman Medical City, Ministry of Health, Saudi Arabia,
(7) Imam Abdulrahman Al-Faisal Hospital, Riyadh, Ministry of Health, Saudi Arabia,
(8) Al-Jadae Primary Health Care Center, Jazan, Ministry of Health, Saudi Arabia,
(9) Farasan General Hospital, Jazan, Ministry of Health, Saudi Arabia,
(10) King Salman Hospital, Riyadh, Ministry of Health, Saudi Arabia,
(11) Badr 3 Primary Health Care Center, Ministry of Health, Saudi Arabia,
(12) Riyadh – Third Health Cluster, Ministry of Health, Saudi Arabia

Abstract

Background: Obstructive Sleep Apnea (OSA) is a highly prevalent yet critically underdiagnosed disorder affecting nearly 1 billion adults globally. It represents a major public health burden, significantly increasing the risk of hypertension, atrial fibrillation, heart failure, stroke, and perioperative complications. Despite its systemic impact, OSA management remains fragmented, with poor coordination between primary care, diagnostic services, therapeutic support, and surgical specialties. Aim: This narrative review synthesizes evidence from 2010-2024 on integrated, multidisciplinary care models for OSA across the entire patient journey, from community screening to long-term management and perioperative safety. Methods: A comprehensive literature search of PubMed, Scopus, CINAHL, and Web of Science was conducted. Thematic analysis integrated findings from sleep medicine, cardiology, anesthesiology, primary care, and nursing literature. Results: Evidence strongly supports that coordinated care pathways—featuring systematic screening in primary care, efficient diagnostic testing, nurse-led titration and adherence programs, and proactive perioperative risk stratification—significantly improve diagnostic rates, positive airway pressure (PAP) adherence, cardiovascular outcomes, and reduce postoperative complications. The failure to integrate these disciplines leads to diagnostic delays, poor treatment adherence, and preventable morbidity. Conclusion: OSA must be managed as a chronic cardiovascular and perioperative risk condition, not an isolated breathing disorder. Effective care requires dismantling silos through standardized protocols, shared electronic health record tools, and dedicated interdisciplinary sleep teams to optimize patient outcomes and health system efficiency.

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References

1. Altree, T. J., Chung, F., Chan, M. T., & Eckert, D. J. (2021). Vulnerability to postoperative complications in obstructive sleep apnea: importance of phenotypes. Anesthesia & Analgesia, 132(5), 1328-1337. DOI: 10.1213/ANE.0000000000005390

2. Azizad, O., & Joshi, G. P. (2023). Day-surgery adult patients with obesity and obstructive sleep apnea: current controversies and concerns. Best Practice & Research Clinical Anaesthesiology, 37(3), 317-330. https://doi.org/10.1016/j.bpa.2022.11.004

3. Bae, E. (2023). Preoperative risk evaluation and perioperative management of patients with obstructive sleep apnea: a narrative review. Journal of dental anesthesia and pain medicine, 23(4), 179. https://doi.org/10.17245/jdapm.2023.23.4.179

4. Bakker, J. P., Weaver, T. E., Parthasarathy, S., & Aloia, M. S. (2019). Adherence to CPAP: what should we be aiming for, and how can we get there?. Chest, 155(6), 1272-1287. https://doi.org/10.1016/j.chest.2019.01.012

5. Benjafield, A. V., Ayas, N. T., Eastwood, P. R., Heinzer, R., Ip, M. S., Morrell, M. J., ... & Malhotra, A. (2019). Estimation of the global prevalence and burden of obstructive sleep apnoea: a literature-based analysis. The Lancet respiratory medicine, 7(8), 687-698. https://doi.org/10.1016/S2213-2600(19)30198-5

6. Bock, J. M., Needham, K. A., Gregory, D. A., Ekono, M. M., Wickwire, E. M., Somers, V. K., & Lerman, A. (2022). Continuous positive airway pressure adherence and treatment cost in patients with obstructive sleep apnea and cardiovascular disease. Mayo Clinic Proceedings: Innovations, Quality & Outcomes, 6(2), 166-175. https://doi.org/10.1016/j.mayocpiqo.2022.01.002

7. Buyse, B., Bruyneel, M., Verbraecken, J., & Testelmans, D. (2022). High adherence to continuous positive airway pressure (CPAP) in patients with obstructive sleep apnea (OSA) in Belgium: a narrative review. Acta Clinica Belgica, 77(3), 710-720. https://doi.org/10.1080/17843286.2021.1943954

8. Carneiro‐Barrera, A., Díaz‐Román, A., Guillén‐Riquelme, A., & Buela‐Casal, G. (2019). Weight loss and lifestyle interventions for obstructive sleep apnoea in adults: systematic review and meta‐analysis. Obesity Reviews, 20(5), 750-762. https://doi.org/10.1111/obr.12824

9. Carneiro-Barrera, A., Amaro-Gahete, F. J., Jurado-Fasoli, L., Sáez-Roca, G., Martín-Carrasco, C., Tinahones, F. J., & Ruiz, J. R. (2022). Effect of a weight loss and lifestyle intervention on dietary behavior in men with obstructive sleep apnea: the INTERAPNEA trial. Nutrients, 14(13), 2731. https://doi.org/10.3390/nu14132731

10. Cheng, Y., Ou, Q., Chen, B., Loffler, K. A., Doug McEvoy, R., Xu, Y., ... & Lao, M. (2023). The changes of AHI after long-term CPAP in patients with comorbid OSA and cardiovascular disease. Sleep and Breathing, 27(2), 511-518. https://doi.org/10.1007/s11325-022-02633-y

11. Chung, F., Memtsoudis, S. G., Ramachandran, S. K., Nagappa, M., Opperer, M., Cozowicz, C., ... & Auckley, D. (2016). Society of anesthesia and sleep medicine guidelines on preoperative screening and assessment of adult patients with obstructive sleep apnea. Anesthesia & Analgesia, 123(2), 452-473. DOI: 10.1213/ANE.0000000000001416

12. Donovan, L. M., Hoyos, C. M., Kimoff, R. J., Morrell, M. J., Bosch, N. A., Chooljian, D. M., ... & Patil, S. P. (2023). Strategies to assess the effect of continuous positive airway pressure on long-term clinically important outcomes among patients with symptomatic obstructive sleep apnea: an official American Thoracic Society workshop report. Annals of the American Thoracic Society, 20(7), 931-943. https://doi.org/10.1513/AnnalsATS.202303-258ST

13. Drager, L. F., McEvoy, R. D., Barbe, F., Lorenzi-Filho, G., & Redline, S. (2017). Sleep apnea and cardiovascular disease: lessons from recent trials and need for team science. Circulation, 136(19), 1840-1850. https://doi.org/10.1161/CIRCULATIONAHA.117.029400

14. Gong, F., Chen, X., Wu, Y., Yao, D., Xie, L., Ouyang, Q., ... & Niu, G. (2018). Nurse vs. physician‐led care for obstructive sleep apnoea: A systematic review and meta‐analysis of randomized trials. Journal of advanced nursing, 74(3), 501-506. https://doi.org/10.1111/jan.13346

15. Hondjeu, A. R. M., Chung, F., & Wong, J. (2022). Perioperative Management of Patients with Obstructive Sleep Apnea. Canadian Journal of General Internal Medicine, 17(S1), 1-16. https://doi.org/10.22374/cjgim.v17iSP1.601

16. Hwang, M., Nagappa, M., Guluzade, N., Saripella, A., Englesakis, M., & Chung, F. (2022). Validation of the STOP-Bang questionnaire as a preoperative screening tool for obstructive sleep apnea: a systematic review and meta-analysis. BMC anesthesiology, 22(1), 366. https://doi.org/10.1186/s12871-022-01912-1

17. Javaheri, S., Barbe, F., Campos-Rodriguez, F., Dempsey, J. A., Khayat, R., Javaheri, S., ... & Somers, V. K. (2017). Sleep apnea: types, mechanisms, and clinical cardiovascular consequences. Journal of the American College of Cardiology, 69(7), 841-858. https://doi.org/10.1016/j.jacc.2016.11.069

18. Joshi, G. P., Ankichetty, S. P., Gan, T. J., & Chung, F. (2012). Society for Ambulatory Anesthesia consensus statement on preoperative selection of adult patients with obstructive sleep apnea scheduled for ambulatory surgery. Anesthesia & Analgesia, 115(5), 1060-1068. DOI: 10.1213/ANE.0b013e318269cfd7

19. Kapur, V. K., Auckley, D. H., Chowdhuri, S., Kuhlmann, D. C., Mehra, R., Ramar, K., & Harrod, C. G. (2017). Clinical practice guideline for diagnostic testing for adult obstructive sleep apnea: an American Academy of Sleep Medicine clinical practice guideline. Journal of clinical sleep medicine, 13(3), 479-504. https://doi.org/10.5664/jcsm.6506

20. Lajoie, A. C., Privé, A., Roy-Hallé, A., Pagé, D., Simard, S., & Séries, F. (2022). Diagnosis and management of sleep apnea by a clinical nurse: a noninferiority randomized clinical trial. Journal of Clinical Sleep Medicine, 18(1), 89-97. https://jcsm.aasm.org/doi/full/10.5664/jcsm.9502#

21. Lockhart, E. M., Willingham, M. D., Abdallah, A. B., Helsten, D. L., Bedair, B. A., Thomas, J., ... & Avidan, M. S. (2013). Obstructive sleep apnea screening and postoperative mortality in a large surgical cohort. Sleep Medicine, 14(5), 407-415. https://doi.org/10.1016/j.sleep.2012.10.018

22. Lukachan, G. A., Yadollahi, A., Auckley, D., Gavrilovic, B., Matelski, J., Chung, F., & Singh, M. (2023). The impact of semi-upright position on severity of sleep disordered breathing in patients with obstructive sleep apnea: a two-arm, prospective, randomized controlled trial. BMC anesthesiology, 23(1), 236. https://doi.org/10.1186/s12871-023-02193-y

23. McEvoy, R. D., Antic, N. A., Heeley, E., Luo, Y., Ou, Q., Zhang, X., ... & Anderson, C. S. (2016). CPAP for prevention of cardiovascular events in obstructive sleep apnea. New England Journal of Medicine, 375(10), 919-931. DOI: 10.1056/NEJMoa1606599

24. Mokhlesi, B., & Tulaimat, A. (2007). Recent advances in obesity hypoventilation syndrome. Chest, 132(4), 1322-1336. https://doi.org/10.1378/chest.07-0027

25. Mutter, T. C., Chateau, D., Moffatt, M., Ramsey, C., Roos, L. L., & Kryger, M. (2014). A matched cohort study of postoperative outcomes in obstructive sleep apnea: could preoperative diagnosis and treatment prevent complications?. Anesthesiology, 121(4), 707-718.

26. O’Donnell, C., Ryan, S., & McNicholas, W. T. (2020). The impact of telehealth on the organization of the health system and integrated care. Sleep Medicine Clinics, 15(3), 431-440. https://doi.org/10.1016/j.jsmc.2020.06.003

27. Patil, S. P., Ayappa, I. A., Caples, S. M., Kimoff, R. J., Patel, S. R., & Harrod, C. G. (2019). Treatment of adult obstructive sleep apnea with positive airway pressure: an American Academy of Sleep Medicine clinical practice guideline. Journal of Clinical Sleep Medicine, 15(2), 335-343. https://doi.org/10.5664/jcsm.7640

28. Pengo, M. F., Soranna, D., Giontella, A., Perger, E., Mattaliano, P., Schwarz, E. I., ... & Fava, C. (2020). Obstructive sleep apnoea treatment and blood pressure: which phenotypes predict a response? A systematic review and meta-analysis. European Respiratory Journal, 55(5). https://doi.org/10.1183/13993003.01945-2019

29. Ramar, K., Dort, L. C., Katz, S. G., Lettieri, C. J., Harrod, C. G., Thomas, S. M., & Chervin, R. D. (2015). Clinical practice guideline for the treatment of obstructive sleep apnea and snoring with oral appliance therapy: an update for 2015: an American Academy of Sleep Medicine and American Academy of Dental Sleep Medicine clinical practice guideline. Journal of clinical sleep medicine, 11(7), 773-827. https://doi.org/10.5664/jcsm.4858

30. Randerath, W., Bassetti, C. L., Bonsignore, M. R., Farre, R., Ferini-Strambi, L., Grote, L., ... & McNicholas, W. T. (2018). Challenges and perspectives in obstructive sleep apnoea: report by an ad hoc working group of the Sleep Disordered Breathing Group of the European Respiratory Society and the European Sleep Research Society. European respiratory journal, 52(3). https://doi.org/10.1183/13993003.02616-2017

31. Shamim-Uzzaman, Q. A., Bae, C. J., Ehsan, Z., Setty, A. R., Devine, M., Dhankikar, S., ... & Epstein, L. J. (2021). The use of telemedicine for the diagnosis and treatment of sleep disorders: an American Academy of Sleep Medicine update. Journal of Clinical Sleep Medicine, 17(5), 1103-1107. https://doi.org/10.5664/jcsm.9194

32. Shaw, J. E., Punjabi, N. M., Wilding, J. P., Alberti, K. G. M., & Zimmet, P. Z. (2008). Sleep-disordered breathing and type 2 diabetes: a report from the International Diabetes Federation Taskforce on Epidemiology and Prevention. Diabetes research and clinical practice, 81(1), 2-12. https://doi.org/10.1016/j.diabres.2008.04.025

33. Soori, R., Baikunje, N., D’sa, I., Bhushan, N., Nagabhushana, B., & Hosmane, G. B. (2022). Pitfalls of AHI system of severity grading in obstructive sleep apnoea. Sleep Science, 15(S 01), 285-288. DOI: 10.5935/1984-0063.20220001

34. Wickwire, E. M., Jobe, S. L., Oldstone, L. M., Scharf, S. M., Johnson, A. M., & Albrecht, J. S. (2020). Lower socioeconomic status and co-morbid conditions are associated with reduced continuous positive airway pressure adherence among older adult medicare beneficiaries with obstructive sleep apnea. Sleep, 43(12), zsaa122. https://doi.org/10.1093/sleep/zsaa122

Authors

Fahd Sari K. Alsharari
Fasaalsharari@moh.gov.sa (Primary Contact)
Sattam Aali Alotaibi
Qoot Naif Ayad Alotaibi
Nasser Saad Hamed Aldossary
Wegdan Husain Ali Mubaraki
Yusra Ali Alatawi
Yousef Jamman Alharbi
Weam Ali Esmael Mobarky
Doaa Salim Hamid Alabsi
Ali Mousa Mobarki
Dr. Othman Mohammed Almousa
Hanan Ahmad Alghamdi
Alsharari, F. S. K., Alotaibi, S. A., Alotaibi, Q. N. A., Aldossary, N. S. H., Mubaraki, W. H. A., Alatawi, Y. A., … Alghamdi, H. A. (2024). Management of Obstructive Sleep Apnea (OSA) Across the Care Continuum: An Interdisciplinary Narrative Review. Saudi Journal of Medicine and Public Health, 1(2), 1898–1905. https://doi.org/10.64483/202412535

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