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Copyright (c) 2024 Fahad Dakhillulah Almutairi, Yousef Mohammed Aloimer, Khalid Manahi Alshahrani, Sahar Gasi Alotaibi, Fawzeiaha Dahar Alanzy, Abdulrazaq Nafia Alanazi, Abdulaziz Dakhilallah Almutairi, Sheikah Abdrhman Ghazei Alotaibi, Ahlam Ali Alnami, Fatmah Abrahim Alshaia, Kathiyh Jaman Alyami, Samirah Ali Ali Mahnasi, Eman Mohammed Almadan

This work is licensed under a Creative Commons Attribution 4.0 International License.
The AI Co-Pilot in Nursing: A Systematic Review of Clinical Decision Support Systems at the Bedside
Corresponding Author(s) : Fahad Dakhillulah Almutairi
Saudi Journal of Medicine and Public Health, Vol. 1 No. 2 (2024)
Abstract
Background: Nursing practice is under significant strain due to workforce shortages and increasing patient acuity. Traditional Clinical Decision Support Systems (CDSS) often lead to "alert fatigue" from vague alarms. The introduction of artificial intelligence, especially machine learning, represents a shift towards predictive, individualized CDSS, intended to assist bedside nurses effectively. Aim: This systematic narrative review synthesizes evidence (2010-2024) on the implementation and impact of AI-powered CDSS in nursing, focusing on applications in deterioration prediction, sepsis detection, and harm prevention. Methods: A systematic search of PubMed, CINAHL, Scopus, and IEEE Xplore databases identified peer-reviewed studies evaluating AI-CDS interventions in acute care nursing. Results: AI-CDSS offers improved predictive accuracy compared to traditional tools, enhancing outcomes such as sepsis bundle compliance and reducing adverse events. Its effect on mortality is ambiguous. Successful integration depends on human-centered design; ineffective systems heighten cognitive load, while effective ones bolster situational awareness. Key findings indicate AI can enhance judgment but may also cause automation bias and diagnostic deskilling. Alert fatigue remains a concern but can be alleviated through tiered, intelligent alerting and closed-loop workflows. Conclusion: The AI co-pilot represents a transformative but complex partner. Its value is realized not through algorithmic superiority alone, but through thoughtful design that supports nursing cognition, integrates seamlessly into workflow, and fosters a culture of calibrated trust, ensuring technology augments rather than displaces essential nursing judgment.
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- Ancker, J. S., Edwards, A., Nosal, S., Hauser, D., Mauer, E., Kaushal, R., & With the HITEC Investigators. (2017). Effects of workload, work complexity, and repeated alerts on alert fatigue in a clinical decision support system. BMC medical informatics and decision making, 17(1), 36. https://doi.org/10.1186/s12911-017-0430-8
- Bartkowiak, B., Snyder, A. M., Benjamin, A., Schneider, A., Twu, N. M., Churpek, M. M., ... & Edelson, D. P. (2019). Validating the electronic cardiac arrest risk triage (eCART) score for risk stratification of surgical inpatients in the postoperative setting: retrospective cohort study. Annals of surgery, 269(6), 1059-1063. DOI: 10.1097/SLA.0000000000002665
- Bedoya, A. D., Clement, M. E., Phelan, M., Steorts, R. C., O’brien, C., & Goldstein, B. A. (2019). Minimal impact of implemented early warning score and best practice alert for patient deterioration. Critical care medicine, 47(1), 49-55. DOI: 10.1097/CCM.0000000000003439
- Buchanan, C., Howitt, M. L., Wilson, R., Booth, R. G., Risling, T., & Bamford, M. (2020). Nursing in the age of artificial intelligence: Protocol for a scoping review. JMIR research protocols, 9(4), e17490. https://doi.org/10.2196/17490
- Buchanan, C., Howitt, M. L., Wilson, R., Booth, R. G., Risling, T., & Bamford, M. (2021). Predicted influences of artificial intelligence on nursing education: scoping review. JMIR nursing, 4(1), e23933. https://doi.org/10.2196/23933
- Cavalier, J. S., O'Brien, C. L., Goldstein, B. A., Zhao, C., & Bedoya, A. (2022). Vitals are Vital: Simpler Clinical Data Model Predicts Decompensation in COVID-19 Patients. ACI Open, 6(01), e34-e38. DOI: 10.1055/s-0042-1749193
- Chu, C. H., Leslie, K., Shi, J., Nyrup, R., Bianchi, A., Khan, S. S., ... & Grenier, A. (2022). Ageism and artificial intelligence: protocol for a scoping review. JMIR Research Protocols, 11(6), e33211. https://doi.org/10.2196/33211
- Churpek, M. M., Yuen, T. C., Winslow, C., Meltzer, D. O., Kattan, M. W., & Edelson, D. P. (2016). Multicenter comparison of machine learning methods and conventional regression for predicting clinical deterioration on the wards. Critical care medicine, 44(2), 368-374. DOI: 10.1097/CCM.0000000000001571
- Darko, E. M., Kleib, M., Lemermeyer, G., & Tavakoli, M. (2023). Robotics in nursing: Protocol for a scoping review. JMIR Research Protocols, 12(1), e50626. https://doi.org/10.2196/50626
- Despins, L. A., Guidoboni, G., Skubic, M., Sala, L., Enayati, M., Popescu, M., & Deroche, C. B. (2020). Using sensor signals in the early detection of heart failure: A case study. Journal of gerontological nursing, 46(7), 41-46. https://doi.org/10.3928/00989134-20200605-07
- Fernandes, F., Santos, P., Sá, L., & Neves, J. (2023). Contributions of artificial intelligence to decision making in nursing: a scoping review protocol. Nursing Reports, 13(1), 67-72. https://doi.org/10.3390/nursrep13010007
- Ferrer, R., Martin-Loeches, I., Phillips, G., Osborn, T. M., Townsend, S., Dellinger, R. P., ... & Levy, M. M. (2014). Empiric antibiotic treatment reduces mortality in severe sepsis and septic shock from the first hour: results from a guideline-based performance improvement program. Critical care medicine, 42(8), 1749-1755. DOI: 10.1097/CCM.0000000000000330
- Haddad, L. M., Annamaraju, P., & Toney-Butler, T. J. (2018). Nursing shortage. In: StatPearls. StatPearls Publishing, Treasure Island (FL).
- Jahandideh, S., Ozavci, G., Sahle, B. W., Kouzani, A. Z., Magrabi, F., & Bucknall, T. (2023). Evaluation of machine learning-based models for prediction of clinical deterioration: A systematic literature review. International Journal of Medical Informatics, 175, 105084. https://doi.org/10.1016/j.ijmedinf.2023.105084
- Kupfer, C., Prassl, R., Fleiß, J., Malin, C., Thalmann, S., & Kubicek, B. (2023). Check the box! How to deal with automation bias in AI-based personnel selection. Frontiers in Psychology, 14, 1118723. https://doi.org/10.3389/fpsyg.2023.1118723
- Lee, H., Yun, D., Yoo, J., Yoo, K., Kim, Y. C., Kim, D. K., ... & Han, S. S. (2021). Deep learning model for real-time prediction of intradialytic hypotension. Clinical Journal of the American Society of Nephrology, 16(3), 396-406. DOI: 10.2215/CJN.09280620
- Lu, T. C., Wang, C. H., Chou, F. Y., Sun, J. T., Chou, E. H., Huang, E. P. C., ... & Huang, C. H. (2023). Machine learning to predict in-hospital cardiac arrest from patients presenting to the emergency department. Internal and Emergency Medicine, 18(2), 595-605. https://doi.org/10.1007/s11739-022-03143-1
- Lyell, D., Magrabi, F., Raban, M. Z., Pont, L. G., Baysari, M. T., Day, R. O., & Coiera, E. (2017). Automation bias in electronic prescribing. BMC medical informatics and decision making, 17(1), 28. https://doi.org/10.1186/s12911-017-0425-5
- Morley, J., Machado, C. C., Burr, C., Cowls, J., Joshi, I., Taddeo, M., & Floridi, L. (2020). The ethics of AI in health care: a mapping review. Social science & medicine, 260, 113172. https://doi.org/10.1016/j.socscimed.2020.113172
- Muralitharan, S., Nelson, W., Di, S., McGillion, M., Devereaux, P. J., Barr, N. G., & Petch, J. (2021). Machine learning–based early warning systems for clinical deterioration: systematic scoping review. Journal of medical Internet research, 23(2), e25187. https://doi.org/10.2196/25187
- Needleman, J., Buerhaus, P., Pankratz, V. S., Leibson, C. L., Stevens, S. R., & Harris, M. (2011). Nurse staffing and inpatient hospital mortality. New England Journal of Medicine, 364(11), 1037-1045. DOI: 10.1056/NEJMsa1001025
- Nyarko, B. A., Nie, H., Yin, Z., Chai, X., & Yue, L. (2023). The effect of educational interventions in managing nurses' alarm fatigue: An integrative review. Journal of clinical nursing, 32(13-14), 2985-2997. https://doi.org/10.1111/jocn.16479
- Oliveira, G. N., Nogueira, L. D. S., & Cruz, D. D. A. L. M. D. (2022). Effect of the national early warning score on monitoring the vital signs of patients in the emergency room. Revista da Escola de Enfermagem da USP, 56, e20210445. https://doi.org/10.1590/1980-220X-REEUSP-2021-0445en
- Page, M. J., McKenzie, J. E., Bossuyt, P. M., Boutron, I., Hoffmann, T. C., Mulrow, C. D., ... & Moher, D. (2021). The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. bmj, 372. https://doi.org/10.1136/bmj.n71
- Russ, A. L., Zillich, A. J., Melton, B. L., Russell, S. A., Chen, S., Spina, J. R., ... & Saleem, J. J. (2014). Applying human factors principles to alert design increases efficiency and reduces prescribing errors in a scenario-based simulation. Journal of the American Medical Informatics Association, 21(e2), e287-e296.
- Sendelbach, S., & Funk, M. (2013). Alarm fatigue: a patient safety concern. AACN advanced critical care, 24(4), 378-386. https://doi.org/10.4037/NCI.0b013e3182a903f9
- Samal, L., Wu, E., Aaron, S., Kilgallon, J. L., Gannon, M., McCoy, A., ... & Wright, A. (2023). Refining clinical phenotypes to improve clinical decision support and reduce alert fatigue: a feasibility study. Applied Clinical Informatics, 14(03), 528-537. DOI: 10.1055/s-0043-1768994
- Song, W., Kang, M. J., Zhang, L., Jung, W., Song, J., Bates, D. W., & Dykes, P. C. (2021). Predicting pressure injury using nursing assessment phenotypes and machine learning methods. Journal of the American Medical Informatics Association, 28(4), 759-765. https://doi.org/10.1093/jamia/ocaa336
- Varghese, J., Kleine, M., Gessner, S. I., Sandmann, S., & Dugas, M. (2018). Effects of computerized decision support system implementations on patient outcomes in inpatient care: a systematic review. Journal of the American Medical Informatics Association, 25(5), 593-602. https://doi.org/10.1093/jamia/ocx100
- Wardi, G., Carlile, M., Holder, A., Shashikumar, S., Hayden, S. R., & Nemati, S. (2021). Predicting progression to septic shock in the emergency department using an externally generalizable machine-learning algorithm. Annals of emergency medicine, 77(4), 395-406. https://doi.org/10.1016/j.annemergmed.2020.11.007
- Wong, A., Otles, E., Donnelly, J. P., Krumm, A., McCullough, J., DeTroyer-Cooley, O., ... & Singh, K. (2021). External validation of a widely implemented proprietary sepsis prediction model in hospitalized patients. JAMA internal medicine, 181(8), 1065-1070. doi:10.1001/jamainternmed.2021.2626
- Wong, G., Greenhalgh, T., Westhorp, G., Buckingham, J., & Pawson, R. (2013). RAMESES publication standards: realist syntheses. BMC medicine, 11(1), 21. https://doi.org/10.1186/1741-7015-11-
References
Ancker, J. S., Edwards, A., Nosal, S., Hauser, D., Mauer, E., Kaushal, R., & With the HITEC Investigators. (2017). Effects of workload, work complexity, and repeated alerts on alert fatigue in a clinical decision support system. BMC medical informatics and decision making, 17(1), 36. https://doi.org/10.1186/s12911-017-0430-8
Bartkowiak, B., Snyder, A. M., Benjamin, A., Schneider, A., Twu, N. M., Churpek, M. M., ... & Edelson, D. P. (2019). Validating the electronic cardiac arrest risk triage (eCART) score for risk stratification of surgical inpatients in the postoperative setting: retrospective cohort study. Annals of surgery, 269(6), 1059-1063. DOI: 10.1097/SLA.0000000000002665
Bedoya, A. D., Clement, M. E., Phelan, M., Steorts, R. C., O’brien, C., & Goldstein, B. A. (2019). Minimal impact of implemented early warning score and best practice alert for patient deterioration. Critical care medicine, 47(1), 49-55. DOI: 10.1097/CCM.0000000000003439
Buchanan, C., Howitt, M. L., Wilson, R., Booth, R. G., Risling, T., & Bamford, M. (2020). Nursing in the age of artificial intelligence: Protocol for a scoping review. JMIR research protocols, 9(4), e17490. https://doi.org/10.2196/17490
Buchanan, C., Howitt, M. L., Wilson, R., Booth, R. G., Risling, T., & Bamford, M. (2021). Predicted influences of artificial intelligence on nursing education: scoping review. JMIR nursing, 4(1), e23933. https://doi.org/10.2196/23933
Cavalier, J. S., O'Brien, C. L., Goldstein, B. A., Zhao, C., & Bedoya, A. (2022). Vitals are Vital: Simpler Clinical Data Model Predicts Decompensation in COVID-19 Patients. ACI Open, 6(01), e34-e38. DOI: 10.1055/s-0042-1749193
Chu, C. H., Leslie, K., Shi, J., Nyrup, R., Bianchi, A., Khan, S. S., ... & Grenier, A. (2022). Ageism and artificial intelligence: protocol for a scoping review. JMIR Research Protocols, 11(6), e33211. https://doi.org/10.2196/33211
Churpek, M. M., Yuen, T. C., Winslow, C., Meltzer, D. O., Kattan, M. W., & Edelson, D. P. (2016). Multicenter comparison of machine learning methods and conventional regression for predicting clinical deterioration on the wards. Critical care medicine, 44(2), 368-374. DOI: 10.1097/CCM.0000000000001571
Darko, E. M., Kleib, M., Lemermeyer, G., & Tavakoli, M. (2023). Robotics in nursing: Protocol for a scoping review. JMIR Research Protocols, 12(1), e50626. https://doi.org/10.2196/50626
Despins, L. A., Guidoboni, G., Skubic, M., Sala, L., Enayati, M., Popescu, M., & Deroche, C. B. (2020). Using sensor signals in the early detection of heart failure: A case study. Journal of gerontological nursing, 46(7), 41-46. https://doi.org/10.3928/00989134-20200605-07
Fernandes, F., Santos, P., Sá, L., & Neves, J. (2023). Contributions of artificial intelligence to decision making in nursing: a scoping review protocol. Nursing Reports, 13(1), 67-72. https://doi.org/10.3390/nursrep13010007
Ferrer, R., Martin-Loeches, I., Phillips, G., Osborn, T. M., Townsend, S., Dellinger, R. P., ... & Levy, M. M. (2014). Empiric antibiotic treatment reduces mortality in severe sepsis and septic shock from the first hour: results from a guideline-based performance improvement program. Critical care medicine, 42(8), 1749-1755. DOI: 10.1097/CCM.0000000000000330
Haddad, L. M., Annamaraju, P., & Toney-Butler, T. J. (2018). Nursing shortage. In: StatPearls. StatPearls Publishing, Treasure Island (FL).
Jahandideh, S., Ozavci, G., Sahle, B. W., Kouzani, A. Z., Magrabi, F., & Bucknall, T. (2023). Evaluation of machine learning-based models for prediction of clinical deterioration: A systematic literature review. International Journal of Medical Informatics, 175, 105084. https://doi.org/10.1016/j.ijmedinf.2023.105084
Kupfer, C., Prassl, R., Fleiß, J., Malin, C., Thalmann, S., & Kubicek, B. (2023). Check the box! How to deal with automation bias in AI-based personnel selection. Frontiers in Psychology, 14, 1118723. https://doi.org/10.3389/fpsyg.2023.1118723
Lee, H., Yun, D., Yoo, J., Yoo, K., Kim, Y. C., Kim, D. K., ... & Han, S. S. (2021). Deep learning model for real-time prediction of intradialytic hypotension. Clinical Journal of the American Society of Nephrology, 16(3), 396-406. DOI: 10.2215/CJN.09280620
Lu, T. C., Wang, C. H., Chou, F. Y., Sun, J. T., Chou, E. H., Huang, E. P. C., ... & Huang, C. H. (2023). Machine learning to predict in-hospital cardiac arrest from patients presenting to the emergency department. Internal and Emergency Medicine, 18(2), 595-605. https://doi.org/10.1007/s11739-022-03143-1
Lyell, D., Magrabi, F., Raban, M. Z., Pont, L. G., Baysari, M. T., Day, R. O., & Coiera, E. (2017). Automation bias in electronic prescribing. BMC medical informatics and decision making, 17(1), 28. https://doi.org/10.1186/s12911-017-0425-5
Morley, J., Machado, C. C., Burr, C., Cowls, J., Joshi, I., Taddeo, M., & Floridi, L. (2020). The ethics of AI in health care: a mapping review. Social science & medicine, 260, 113172. https://doi.org/10.1016/j.socscimed.2020.113172
Muralitharan, S., Nelson, W., Di, S., McGillion, M., Devereaux, P. J., Barr, N. G., & Petch, J. (2021). Machine learning–based early warning systems for clinical deterioration: systematic scoping review. Journal of medical Internet research, 23(2), e25187. https://doi.org/10.2196/25187
Needleman, J., Buerhaus, P., Pankratz, V. S., Leibson, C. L., Stevens, S. R., & Harris, M. (2011). Nurse staffing and inpatient hospital mortality. New England Journal of Medicine, 364(11), 1037-1045. DOI: 10.1056/NEJMsa1001025
Nyarko, B. A., Nie, H., Yin, Z., Chai, X., & Yue, L. (2023). The effect of educational interventions in managing nurses' alarm fatigue: An integrative review. Journal of clinical nursing, 32(13-14), 2985-2997. https://doi.org/10.1111/jocn.16479
Oliveira, G. N., Nogueira, L. D. S., & Cruz, D. D. A. L. M. D. (2022). Effect of the national early warning score on monitoring the vital signs of patients in the emergency room. Revista da Escola de Enfermagem da USP, 56, e20210445. https://doi.org/10.1590/1980-220X-REEUSP-2021-0445en
Page, M. J., McKenzie, J. E., Bossuyt, P. M., Boutron, I., Hoffmann, T. C., Mulrow, C. D., ... & Moher, D. (2021). The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. bmj, 372. https://doi.org/10.1136/bmj.n71
Russ, A. L., Zillich, A. J., Melton, B. L., Russell, S. A., Chen, S., Spina, J. R., ... & Saleem, J. J. (2014). Applying human factors principles to alert design increases efficiency and reduces prescribing errors in a scenario-based simulation. Journal of the American Medical Informatics Association, 21(e2), e287-e296.
Sendelbach, S., & Funk, M. (2013). Alarm fatigue: a patient safety concern. AACN advanced critical care, 24(4), 378-386. https://doi.org/10.4037/NCI.0b013e3182a903f9
Samal, L., Wu, E., Aaron, S., Kilgallon, J. L., Gannon, M., McCoy, A., ... & Wright, A. (2023). Refining clinical phenotypes to improve clinical decision support and reduce alert fatigue: a feasibility study. Applied Clinical Informatics, 14(03), 528-537. DOI: 10.1055/s-0043-1768994
Song, W., Kang, M. J., Zhang, L., Jung, W., Song, J., Bates, D. W., & Dykes, P. C. (2021). Predicting pressure injury using nursing assessment phenotypes and machine learning methods. Journal of the American Medical Informatics Association, 28(4), 759-765. https://doi.org/10.1093/jamia/ocaa336
Varghese, J., Kleine, M., Gessner, S. I., Sandmann, S., & Dugas, M. (2018). Effects of computerized decision support system implementations on patient outcomes in inpatient care: a systematic review. Journal of the American Medical Informatics Association, 25(5), 593-602. https://doi.org/10.1093/jamia/ocx100
Wardi, G., Carlile, M., Holder, A., Shashikumar, S., Hayden, S. R., & Nemati, S. (2021). Predicting progression to septic shock in the emergency department using an externally generalizable machine-learning algorithm. Annals of emergency medicine, 77(4), 395-406. https://doi.org/10.1016/j.annemergmed.2020.11.007
Wong, A., Otles, E., Donnelly, J. P., Krumm, A., McCullough, J., DeTroyer-Cooley, O., ... & Singh, K. (2021). External validation of a widely implemented proprietary sepsis prediction model in hospitalized patients. JAMA internal medicine, 181(8), 1065-1070. doi:10.1001/jamainternmed.2021.2626
Wong, G., Greenhalgh, T., Westhorp, G., Buckingham, J., & Pawson, R. (2013). RAMESES publication standards: realist syntheses. BMC medicine, 11(1), 21. https://doi.org/10.1186/1741-7015-11-