The Biopsychosocial Management of Perinatal Pelvic Girdle Pain: From Biomarkers to Mobility
Abstract
Background: Perinatal Pelvic Girdle Pain (PPGP) is a highly prevalent and disabling condition affecting up to 50% of pregnant and postpartum individuals, characterized by pain in the sacroiliac joints, pubic symphysis, and surrounding structures. Its etiology is multifactorial, involving biomechanical, hormonal, and psychosocial factors, yet clinical management often remains fragmented and biomechanically focused. This approach overlooks the significant psychological distress and potential systemic inflammatory components that modulate pain experience and disability. Aim: This narrative review synthesizes contemporary literature (2010-2024) to propose an integrated biopsychosocial model for PPGP management. It examines the roles of midwifery, physical therapy, psychology, and medical laboratory science in screening, assessing, and treating pain from a holistic perspective. Methods: A systematic search of PubMed, CINAHL, PsycINFO, and Scopus databases identified peer-reviewed articles on PPGP epidemiology, biomechanics, psychological correlates, inflammatory biomarkers, and intervention studies. Results: PPGP is best understood as a biopsychosocial phenomenon. Midwifery provides essential first-line screening and supportive care. Physical therapy offers effective biomechanical interventions, but their efficacy is enhanced when combined with psychological strategies targeting pain catastrophizing and kinesiophobia. Emerging evidence suggests low-grade systemic inflammation, measurable via biomarkers like CRP and IL-6, may correlate with pain severity and chronicity, offering a potential objective guide for treatment stratification. Conclusion: Optimal management of PPGP requires a coordinated, interdisciplinary approach. Moving beyond a purely structural model to one that integrates biomechanical correction, psychological support, and biomarker-informed care can improve functional outcomes, reduce the transition to chronic pain, and enhance the perinatal experience.
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References
Abdelnaeem, A. O., Vining, R., & Rehan Youssef, A. (2019). Classification of pregnancy-related non-specific low back pain and pelvic girdle pain: a systematic review. Physical Therapy Reviews, 24(3-4), 156-174. https://doi.org/10.1080/10833196.2019.1637600
Ali, A., Andrzejowski, P., Kanakaris, N. K., & Giannoudis, P. V. (2020). Pelvic girdle pain, hypermobility spectrum disorder and hypermobility-type ehlers-danlos syndrome: A narrative literature review. Journal of Clinical Medicine, 9(12), 3992. https://doi.org/10.3390/jcm9123992
Beales, D. J., O'Sullivan, P. B., & Briffa, N. K. (2010). The effects of manual pelvic compression on trunk motor control during an active straight leg raise in chronic pelvic girdle pain subjects. Manual therapy, 15(2), 190-199. https://doi.org/10.1016/j.math.2009.10.008
Drejza, M. A., Rylewicz, K., Majcherek, E., Gross-Tyrkin, K., Mizgier, M., Plagens-Rotman, K., ... & Jarząbek-Bielecka, G. (2022). Markers of oxidative stress in obstetrics and Gynaecology—a systematic literature review. Antioxidants, 11(8), 1477. https://doi.org/10.3390/antiox11081477
Elden, H., Gutke, A., Kjellby-Wendt, G., Fagevik-Olsen, M., & Ostgaard, H. C. (2016). Predictors and consequences of long-term pregnancy-related pelvic girdle pain: a longitudinal follow-up study. BMC musculoskeletal disorders, 17(1), 276. https://doi.org/10.1186/s12891-016-1154-0
Gashaw, M., Yitayal, M. M., Zemed, A., Nigatu, S. G., Kasaw, A., Belay, D. G., ... & Janakiraman, B. (2022). Level of activity limitations and predictors in women with pregnancy-related pelvic girdle pain: Prospective cross-sectional study. Annals of Medicine and Surgery, 78, 103754. https://doi.org/10.1016/j.amsu.2022.103754
Gatchel, R. J., McGeary, D. D., McGeary, C. A., & Lippe, B. (2014). Interdisciplinary chronic pain management: past, present, and future. American psychologist, 69(2), 119. https://psycnet.apa.org/doi/10.1037/a0035514
Kablan, N., Ayvacı, H., Can, M., Tatar, Y., Kumru, P., & Şahin, S. (2022). The effect of gestational diabetes mellitus on occurrence of the pelvic girdle pain and symptom severity in pregnant women. Journal of Obstetrics and Gynaecology, 42(6), 2058-2063. https://doi.org/10.1080/01443615.2022.2081491
Kamper, S. J., Apeldoorn, A. T., Chiarotto, A., Smeets, R. J., Ostelo, R. W., Guzman, J., & van Tulder, M. (2015). Multidisciplinary biopsychosocial rehabilitation for chronic low back pain: Cochrane systematic review and meta-analysis. Bmj, 350. https://doi.org/10.1136/bmj.h444
Karaaslan, Y., Ucuzoglu, M. E., Yüksel, S., & Yılmaz Yalçınkaya, E. (2023). The relationship of pain, disability, physical activity, and body awareness with kinesiophobia in pregnant women with low back pain. Somatosensory & Motor Research, 40(4), 156-160. https://doi.org/10.1080/08990220.2023.2263547
Lepri, B., Romani, D., Storari, L., & Barbari, V. (2023). Effectiveness of pain neuroscience education in patients with chronic musculoskeletal pain and central sensitization: a systematic review. International journal of environmental research and public health, 20(5), 4098. https://doi.org/10.26603/001c.118179
Louw, A., Zimney, K., Puentedura, E. J., & Diener, I. (2016). The efficacy of pain neuroscience education on musculoskeletal pain: a systematic review of the literature. Physiotherapy theory and practice, 32(5), 332-355. https://doi.org/10.1080/09593985.2016.1194646
Mapinduzi, J., Ndacayisaba, G., Mahaudens, P., & Hidalgo, B. (2022). Effectiveness of motor control exercises versus other musculoskeletal therapies in patients with pelvic girdle pain of sacroiliac joint origin: A systematic review with meta-analysis of randomized controlled trials. Journal of back and musculoskeletal rehabilitation, 35(4), 713-728. https://doi.org/10.3233/BMR-210108
Mamipour, H., Farazmehr, S., Negahban, H., Nazary-Moghadam, S., Dehghan-Manshadi, F., Nezhad, M. N., ... & Sharifzadeh, M. (2023). Effect of core stabilization exercises on pain, functional disability, and quality of life in pregnant women with lumbar and pelvic girdle pain: A randomized controlled trial. Journal of Manipulative and Physiological Therapeutics, 46(1), 27-36. https://doi.org/10.1016/j.jmpt.2023.05.005
Mens, J. M., Pool-Goudzwaard, A., & Stam, H. J. (2009). Mobility of the pelvic joints in pregnancy-related lumbopelvic pain: a systematic review. Obstetrical & gynecological survey, 64(3), 200-208. DOI: 10.1097/OGX.0b013e3181950f1b
Mens, J. M., & Pool-Goudzwaard, A. (2017). The transverse abdominal muscle is excessively active during active straight leg raising in pregnancy-related posterior pelvic girdle pain: an observational study. BMC musculoskeletal disorders, 18(1), 372. https://doi.org/10.1186/s12891-017-1732-9
Olsson, C., & Lena, N. W. (2004). Health-related quality of life and physical ability among pregnant women with and without back pain in late pregnancy. Acta obstetricia et gynecologica Scandinavica, 83(4), 351-357. https://doi.org/10.1080/j.0001-6349.2004.00384.x
Pellerino, A., Verdijk, R. M., Nichelli, L., Andratschke, N. H., Idbaih, A., & Goldbrunner, R. (2023). Diagnosis and treatment of peripheral and cranial nerve tumors with expert recommendations: An EUropean Network for RAre CANcers (EURACAN) initiative. Cancers, 15(7), 1930. https://doi.org/10.3390/cancers15071930
Rexelius, N., Lindgren, A., Torstensson, T., Kristiansson, P., & Turkmen, S. (2020). Sexuality and mood changes in women with persistent pelvic girdle pain after childbirth: a case-control study. BMC Women's Health, 20(1), 201. https://doi.org/10.1186/s12905-020-01058-7
Robinson, H. S., Veierød, M. B., Mengshoel, A. M., & Vøllestad, N. K. (2010). Pelvic girdle pain-associations between risk factors in early pregnancy and disability or pain intensity in late pregnancy: a prospective cohort study. BMC musculoskeletal disorders, 11(1), 91. https://doi.org/10.1186/1471-2474-11-91
Sakamoto, A., & Gamada, K. (2019). Altered musculoskeletal mechanics as risk factors for postpartum pelvic girdle pain: a literature review. Journal of Physical Therapy Science, 31(10), 831-838. https://doi.org/10.1589/jpts.31.831
Santos, F. F., Lourenço, B. M., Souza, M. B., Maia, L. B., Oliveira, V. C., & Oliveira, M. X. (2023). Prevention of low back and pelvic girdle pain during pregnancy: a systematic review and meta-analysis of randomised controlled trials with GRADE recommendations. Physiotherapy, 118, 1-11. https://doi.org/10.1016/j.physio.2022.09.004
Starzec-Proserpio, M., Rejano-Campo, M., Szymańska, A., Szymański, J., & Baranowska, B. (2022). The association between postpartum pelvic girdle pain and pelvic floor muscle function, diastasis recti and psychological factors—a matched case-control study. International Journal of Environmental Research and Public Health, 19(10), 6236. https://doi.org/10.3390/ijerph19106236
Stuge, B., Jenssen, H. K., & Grotle, M. (2017). The pelvic girdle questionnaire: responsiveness and minimal important change in women with pregnancy-related pelvic girdle pain, low back pain, or both. Physical therapy, 97(11), 1103-1113. https://doi.org/10.1093/ptj/pzx078
Stuge, B. (2019). Evidence of stabilizing exercises for low back-and pelvic girdle pain–a critical review. Brazilian journal of physical therapy, 23(2), 181-186. https://doi.org/10.1016/j.bjpt.2018.11.006
Vleeming, A., Albert, H. B., Östgaard, H. C., Sturesson, B., & Stuge, B. (2008). European guidelines for the diagnosis and treatment of pelvic girdle pain. European Spine Journal, 17(6), 794-819. https://doi.org/10.1007/s00586-008-0602-4
Vlaeyen, J. W. (2016). The intricate relationship amongst pain intensity, fear and avoidance. Scandinavian journal of pain, 13(1), 128-129. https://doi.org/10.1016/j.sjpain.2016.08.010
Wiezer, M., Hage-Fransen, M. A. H., Otto, A., Wieffer-Platvoet, M. S., Slotman, M. H., Nijhuis-Van der Sanden, M. W. G., & Pool-Goudzwaard, A. L. (2020). Risk factors for pelvic girdle pain postpartum and pregnancy related low back pain postpartum; a systematic review and meta-analysis. Musculoskeletal Science and Practice, 48, 102154. https://doi.org/10.1016/j.msksp.2020.102154
Wong, G., Greenhalgh, T., Westhorp, G., Buckingham, J., & Pawson, R. (2013). RAMESES publication standards: realist syntheses. BMC medicine, 11(1), 21. https://doi.org/10.1186/1741-7015-11-21
Wuytack, F., Daly, D., Curtis, E., & Begley, C. (2018). Prognostic factors for pregnancy-related pelvic girdle pain, a systematic review. Midwifery, 66, 70-78. https://doi.org/10.1016/j.midw.2018.07.012
Authors
Copyright (c) 2024 Fahad Mohammed Al-Bahli, Turki Khaid Alotibi, Muhammad Khaled Al-Mughairy, Fahad Mohammed Al-Bahli, Saleh Mohammed Faleh Alshammari, Haifa Abdulaziz Ali Alobaida, Norah Abdullah Naser Algaseem, Ghallab Habbab Alharbi, Mohammed Essa Mohammed Abutawil, Ahmed Mohammed Hussain Darbashi, Eissa Modhi Almutairi, Hussain Ali Ahmad Moafa, Ahmed Muraiziq Alharbi

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